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TD52

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Chemical Structure| 1798328-24-1 同义名 : -
CAS号 : 1798328-24-1
货号 : A1338559
分子式 : C24H16N4
纯度 : 99%+
分子量 : 360.411
MDL号 : MFCD31697737
存储条件：

粉末 Keep in dark place,Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(291.33 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 TD52, a derivative of Erlotinib, is an orally active and potent inhibitor of protein phosphatase 2A (CIP2A). It induces apoptosis in triple-negative breast cancer (TNBC) cells by modulating the CIP2A/PP2A/p-Akt signaling pathway. TD52 indirectly decreases CIP2A levels by disrupting Elk1 binding to the CIP2A promoter. Despite exhibiting lower inhibition of p-EGFR, TD52 demonstrates significant anti-cancer activity [1]. TD52 functions as a click chemistry reagent, featuring an alkyne group enabling it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing azide groups.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.77mL

0.55mL

0.28mL

13.87mL

2.77mL

1.39mL

27.75mL

5.55mL

2.77mL
参考文献

[1]Chun-Yu Liu, et al. EGFR-independent Elk1/CIP2A signalling mediates apoptotic effect of an erlotinib derivative TD52 in triple-negative breast cancer cells. Eur J Cancer. 2017 Feb;72:112-123.