产品说明书
Lixumistat
 |
同义名 : | IM156 free base;HL156A free base;HL156A;IM156;HL271 free base |
| CAS号 : | 1422365-93-2 | |
| 货号 : | A1327296 | |
| 分子式 : | C13H16F3N5O | |
| 纯度 : | 99%+ | |
| 分子量 : | 315.294 | |
| MDL号 : | MFCD32856762 | |
| 存储条件： |
粉末 Keep in dark place,Inert atmosphere,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Lixumistat (IM156) is a newly developed biguanide mitochondrial protein complex 1 inhibitor targeting oxidative phosphorylation (OXPHOS), displaying anti-tumor effects. Lixumistat modulates OXPHOS to mitigate mitochondrial metabolic reprogramming and suppress lung fibrosis. Additionally, Lixumistat inhibits B-cell activation, thereby alleviating symptoms of systemic lupus erythematosus [1][5]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
3.17mL 0.63mL 0.32mL |
15.86mL 3.17mL 1.59mL |
31.72mL 6.34mL 3.17mL |
