Menadione
产品说明书
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同义名 : | 维生素K3 ;Vitamin K3;NSC 4170;Menadione bisulfite;Vikasol;Vicasol;Vitamin K3 sodium bisulfite;Thyloquinone;Menaphthone;2-Methyl-1,4-naphthoquinone |
| CAS号 : | 58-27-5 | |
| 货号 : | A129193 | |
| 分子式 : | C11H8O2 | |
| 纯度 : | 98% | |
| 分子量 : | 172.18 | |
| MDL号 : | MFCD00001681 | |
| 存储条件： |
Pure form Keep in dark place,Sealed in dry,Room Temperature In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 120 mg/mL(696.95 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO 无水乙醇: 8 mg/mL(46.46 mM)，配合低频超声助溶，注意：无水乙醇开封后，易挥发，也会吸收空气中的水分，导致溶解能力下降，请避免使用开封较久的乙醇 |
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| 动物实验配方： |
IP 2% DMSO+2% Tween80+30% PEG300+water 2.6 mg/mL clear PO 0.5% CMC-Na 30 mg/mL suspension |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Menadione, a naphthoquinone, transforms into active vitamin K2 within the body. It has potential uses as both an anticancer compound and a radiosensitizer[1]. | ||
| 细胞研究 | |||||
|---|---|---|---|---|---|
| 细胞系 | 浓度 | 检测类型 | 检测时间 | 活性说明 | 数据源 |
| CRL2796 cells | Cytotoxicity assay | Cytotoxicity against human CRL2796 cells assessed as inhibition of formazan formation at day 4 by measuring absorbance at 430 nm, IC50=21 μM | 19969400 | ||
| DU145 cells | Cytotoxicity assay | 72 h | Cytotoxicity against human DU145 cells assessed as growth inhibition after 72 hrs by MTS assay, IC50=9.86 μM | 23791367 | |
| HaCaT cells | Function assay | 48 h | Antihyperproliferative activity against human HaCaT cells assessed as inhibition of cell growth after 48 hrs by phase contrast microscopy, IC50=15.8 μM | 24964246 | |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
5.81mL 1.16mL 0.58mL |
29.04mL 5.81mL 2.90mL |
58.08mL 11.62mL 5.81mL |
| 参考文献 |
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