产品说明书

ML604086

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Chemical Structure| 850330-18-6 同义名 : -
CAS号 : 850330-18-6
货号 : A1271007
分子式 : C27H32N4O4S
纯度 : 98%
分子量 : 508.632
MDL号 : MFCD32201065
存储条件：

粉末 Keep in dark place,Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 115 mg/mL(226.1 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 ML604086 is a selective CCR8 inhibitor that inhibits CCL1 from binding to CCR8 on circulating T cells. ML604086 inhibits CCL1-mediated chemotaxis and increases intracellularCa2+ concentration[1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.97mL

0.39mL

0.20mL

9.83mL

1.97mL

0.98mL

19.66mL

3.93mL

1.97mL
参考文献

[1]James E. Pease, et al. Chemokine Receptors in Allergy, Inflammation, and Infectious Disease. Top Med Chem (2015) 14: 1-40.

[2]Lin Wang, et al. Antagonism of chemokine receptor CCR8 is ineffective in a primate model of asthma. Thorax 2013;68:506–512.