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Enalapril Maleate

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Chemical Structure| 76095-16-4 同义名 : 依那普利马来酸盐 ;MK-421 maleate;Enalapril (maleate)
CAS号 : 76095-16-4
货号 : A126648
分子式 : C24H32N2O9
纯度 : 98%
分子量 : 492.52
MDL号 : MFCD00133304
存储条件：

粉末 Keep in dark place,Inert atmosphere,Room temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(101.52 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 30 mg/mL(60.91 mM)
动物实验配方：
生物活性
靶点

  • ACE
描述 Enalapril Maleate, the active metabolite of enalapril, is an angiotensin-converting enzyme (ACE) inhibitor. Absorption of enalapril maleate (10 mg, p.o.) was rapid, with peak serum concentrations of enalapril observed 0.5-1.5 h after administration[3]. Moreover, treatment with the ACE inhibitor enalapril maleate improved UVB-induced(ultraviolet B) wrinkles and skin damage in hairless mouse skin[4]. Enalapril maleate and folic acid tablets have a protective effect against CIN (contrast-induced nephropathy) in diabetic rats[5].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00603590 Cardiovascular Disease ... 展开 >> Hypertension Hyperlipidemia Heart Disease 收起 << Phase 2 Completed - Iran, Islamic Republic of ... 展开 >> Kalaleh Heart Study Center Kalaleh, Golestan, Iran, Islamic Republic of 收起 <<
NCT00603590 - Completed - -
NCT02639637 Type 2 Diabetes Mellitus Phase 4 Completed - United States, Tennessee ... 展开 >> Vanderbilt University Medical Center Nashville, Tennessee, United States, 37232 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.03mL

0.41mL

0.20mL

10.15mL

2.03mL

1.02mL

20.30mL

4.06mL

2.03mL
参考文献

[1]Knowles JW, Reddick RL, et al. Enhanced atherosclerosis and kidney dysfunction in eNOS(-/-)Apoe(-/-) mice are ameliorated by enalapril treatment. J Clin Invest. 2000 Feb;105(4):451-8.

[2]Vlasses PH, Larijani GE, et al. Enalapril, a nonsulfhydryl angiotensin-converting enzyme inhibitor. Clin Pharm. 1985 Jan-Feb;4(1):27-40.

[3]Ulm EH, Hichens M, Gomez HJ, Till AE, Hand E, Vassil TC, Biollaz J, Brunner HR, Schelling JL. Enalapril maleate and a lysine analogue (MK-521): disposition in man. Br J Clin Pharmacol. 1982 Sep;14(3):357-62. doi: 10.1111/j.1365-2125.1982.tb01991.x. PMID: 6289858; PMCID: PMC1427630.

[4]Matsuura-Hachiya Y, Nakai Y, Abe K, Nishiyama T, Arai KY. Recovery of extracellular matrix components by enalapril maleate during the repair process of ultraviolet B-induced wrinkles in mouse skin. Biochem Biophys Rep. 2015 Sep 21;4:180-186. doi: 10.1016/j.bbrep.2015.09.012. PMID: 29124203; PMCID: PMC5668924.

[5]Hou J, Yan G, Liu B, Zhu B, Qiao Y, Wang D, Li R, Luo E, Tang C. The Protective Effects of Enalapril Maleate and Folic Acid Tablets against Contrast-Induced Nephropathy in Diabetic Rats. Biomed Res Int. 2018 Feb 7;2018:4609750. doi: 10.1155/2018/4609750. PMID: 29560361; PMCID: PMC5820582.