产品说明书

DCLK1-IN-1

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Chemical Structure| 2222635-15-4 同义名 : -
CAS号 : 2222635-15-4
货号 : A1263123
分子式 : C26H28F3N7O2
纯度 : 99%+
分子量 : 527.541
MDL号 : MFCD32671365
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 35 mg/mL(66.35 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 DCLK1-IN-1 is a selective chemical probe with oral bioavailability and in vivo compatibility, targeting the doublecortin like kinase 1 (DCLK1 kinase) domain. It inhibits both DCLK1 and DCLK2 kinases (IC50: DCLK1=9.5/57.2 nM and DCLK2=31/103 nM in binding and kinase assays, respectively). DCLK1-IN-1 demonstrates low toxicity, enabling investigation into DCLK1 biology and its role in cancers such as DCLK1+ pancreatic ductal adenocarcinoma (PDAC) [1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.90mL

0.38mL

0.19mL

9.48mL

1.90mL

0.95mL

18.96mL

3.79mL

1.90mL
参考文献

[1]Ferguson FM, et al. Discovery of a selective inhibitor of doublecortin like kinase 1. Nat Chem Biol. 2020 Apr 6.