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Amikacin disulfate

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Chemical Structure| 39831-55-5 同义名 : 阿米卡星硫酸盐 ;BAY 41-6551 disulfate;BB-K8
CAS号 : 39831-55-5
货号 : A125426
分子式 : C22H47N5O21S2
纯度 : 98% (contains ~10%H2O)
分子量 : 781.76
MDL号 : MFCD00167475
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

H2O: 100 mg/mL(127.92 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 Amikacin (disulfate), a semisynthetic analog of kanamycin, is very active against most gram-negative bacteria including gentamicin- and tobramycin-resistant strains. High response rates have been reported with the use of amikacin combined with beta-lactam antibiotics in immunocompromised or granulocytopenic patients[3]. Amikacin is useful against gentamicin-resistant gram-negative bacilli and also in the treatment of infections caused by susceptible Nocardia and nontuberculous mycobacteria[4]. Moreover, amikacin 20 mg/kg once daily provided a higher probability of target attainment with lower toxicity than dosing three times daily[5].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.28mL

0.26mL

0.13mL

6.40mL

1.28mL

0.64mL

12.79mL

2.56mL

1.28mL
参考文献

[1]Umezawa H. Studies on aminoglycoside antibiotics: enzymic mechanism of resistance and genetics. Jpn J Antibiot. 1979 Dec;32 Suppl:S1-14.

[2]Kluge RM, Standiford HC, et al. Comparative activity of tobramycin, amikacin, and gentamicin alone and with carbenicillin against Pseudomonas aeruginosa. Antimicrob Agents Chemother. 1974 Oct;6(4):442-6.

[3]Ristuccia AM, Cunha BA. An overview of amikacin. Ther Drug Monit. 1985;7(1):12-25.

[4]Edson RS, Terrell CL. The aminoglycosides. Mayo Clin Proc. 1999 May;74(5):519-28.

[5]Alqahtani S, Abouelkheir M, Alsultan A, Elsharawy Y, Alkoraishi A, Osman R, Mansy W. Optimizing Amikacin Dosage in Pediatrics Based on Population Pharmacokinetic/Pharmacodynamic Modeling. Paediatr Drugs. 2018 Jun;20(3):265-272.