产品说明书
Dooku1
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同义名 : | - |
| CAS号 : | 2253744-54-4 | |
| 货号 : | A1251856 | |
| 分子式 : | C13H9Cl2N3OS | |
| 纯度 : | 99%+ | |
| 分子量 : | 326.201 | |
| MDL号 : | MFCD32174346 | |
| 存储条件： |
粉末 Sealed in dry,Room Temperature 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(321.89 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Dooku1 acts as a reversible antagonist of Yoda1, with IC50 values of 1.3 μM and 1.5 μM for Yoda1-induced Ca2+ entry in HEK 293 cells and HUVECs at a Yoda1 concentration of 2 μM, respectively. It interferes with Yoda1-induced Piezo1 channel activity and inhibits Yoda1-induced relaxation of the aorta. Dooku1 is applicable for research in vascular physiology and disease[1]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
3.07mL 0.61mL 0.31mL |
15.33mL 3.07mL 1.53mL |
30.66mL 6.13mL 3.07mL |
| 参考文献 |
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