LP-935509

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Chemical Structure| 1454555-29-3 同义名 : -
CAS号 : 1454555-29-3
货号 : A1251842
分子式 : C20H24N6O3
纯度 : 99%+
分子量 : 396.443
MDL号 : MFCD31689756
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(126.12 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 LP-935509 is an orally active, potent, selective, ATP-competitive, and brain-penetrating inhibitor of AAK1 with an IC50 value of 3.3 nM and a Ki value of 0.9 nM. LP-935509 is also a potent inhibitor of BIKE (IC50=14 nM) and a mild inhibitor of GAK (IC50=320 nM). LP-935509 has antinociceptive activity and can be used in neuropathic pain and SARS-CoV-2 studies.The IC50 value of LP-935509 for inhibition of μ2 protein phosphorylation is 2.8 ± 0.4 nM, and for inhibition of μ2 protein polypeptide phosphorylation is 3.3 ± 0.7 nM[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.52mL

0.50mL

0.25mL

12.61mL

2.52mL

1.26mL

25.22mL

5.04mL

2.52mL
参考文献

[1]Kostich W, et al. Inhibition of AAK1 Kinase as a Novel Therapeutic Approach to Treat Neuropathic Pain. J Pharmacol Exp Ther. 2016 Sep;358(3):371-86.