ZLDI-8

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Chemical Structure| 667880-38-8 同义名 : -
CAS号 : 667880-38-8
货号 : A1250008
分子式 : C24H23N3O3S
纯度 : 98%+
分子量 : 433.523
MDL号 : MFCD03699567
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 60 mg/mL(138.4 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 ZLDI-8 acts as an inhibitor of the Notch activating/cleaving enzyme ADAM-17, preventing Notch protein cleavage. It reduces the levels of proteins associated with survival, anti-apoptosis, and epithelial-mesenchymal transition (EMT). Furthermore, ZLDI-8 serves as a competitive and irreversible inhibitor of tyrosine phosphatase (Lyp), exhibiting an IC50 of 31.6 μM and a Ki of 26.22 μM. It effectively curbs the proliferation of MHCC97-H cells with an IC50 of 5.32 μM[1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.31mL

0.46mL

0.23mL

11.53mL

2.31mL

1.15mL

23.07mL

4.61mL

2.31mL
参考文献

[1]Zhang Y, et al. Novel ADAM-17 inhibitor ZLDI-8 enhances the in vitro and in vivo chemotherapeutic effects of Sorafenib on hepatocellular carcinoma cells. Cell Death Dis. 2018 Jul 3;9(7):743.

[2]Hou X, et al. Fast identification of novel lymphoid tyrosine phosphatase inhibitors using target-ligand interaction-based virtual screening. J Med Chem. 2014 Nov 26;57(22):9309-22.