BV02

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Chemical Structure| 292870-53-2 同义名 : -
CAS号 : 292870-53-2
货号 : A1249666
分子式 : C20H15N3O5
纯度 : 98%
分子量 : 377.35
MDL号 : MFCD00356631
存储条件：

粉末 Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 12 mg/mL(31.8 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 BV02 is a potent 14-3-3 protein-protein interaction inhibitor. BV02 is cytotoxic to imatinib mesylate-sensitive wild-type Bcr-Abl and imatinib mesylate-resistant T315I mutant haematopoietic cells. BV02 has potential for the study of chronic granulocytic leukaemia [1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.65mL

0.53mL

0.27mL

13.25mL

2.65mL

1.33mL

26.50mL

5.30mL

2.65mL
参考文献

[1]Valensin D, et al. Molecular insights to the bioactive form of BV02, a reference inhibitor of 14-3-3σ protein-protein interactions. Bioorg Med Chem Lett. 2016 Feb 1;26(3):894-898.

[2]Mancini M, et al. A new nonpeptidic inhibitor of 14-3-3 induces apoptotic cell death in chronic myeloid leukemia sensitive or resistant to imatinib. J Pharmacol Exp Ther. 2011 Mar;336(3):596-604.