EF24

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Chemical Structure| 342808-40-6 同义名 : -
CAS号 : 342808-40-6
货号 : A1249419
分子式 : C19H15F2NO
纯度 : 99%
分子量 : 311.325
MDL号 : MFCD08560185
存储条件：

Pure form Inert atmosphere,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(160.6 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 EF24 is a curcumin analogue but with stronger antitumour efficacy and oral bioavailability. In oral squamous cell carcinoma cells, EF24 achieves higher anti-tumour efficacy by interfering with the MAPK/ERK signalling pathway. EF24 increases the levels of activated caspase 3 and caspase 9 and decreases the phosphorylated forms of MEK1 and ERK[1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.21mL

0.64mL

0.32mL

16.06mL

3.21mL

1.61mL

32.12mL

6.42mL

3.21mL
参考文献

[1]Lelli D, et al. Curcumin and treatment of melanoma: The potential role of microRNAs. Biomed Pharmacother. 2017 Apr;88:832-834.

[2]Mosley CA, et al. Highly active anticancer curcumin analogues. Adv Exp Med Biol. 2007;595:77-103.