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Chromeceptin

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Chemical Structure| 331859-86-0 同义名 : 94G6
CAS号 : 331859-86-0
货号 : A1249317
分子式 : C19H16F3N3O
纯度 : 99%+
分子量 : 359.345
MDL号 : MFCD00815850
存储条件：

粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(292.2 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Chromeceptin is an inhibitor of the IGF signalling pathway. Chromeceptin inhibits IGF2 expression at the mRNA and protein levels in hepatocytes and HCC cells. Chromeceptin inhibits the phosphorylation levels of AKT and mTOR. At a concentration of 5 µM, Chromeceptin inhibits IGF2 expression in Hep3B-derived TS cells in a time-dependent manner[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.78mL

0.56mL

0.28mL

13.91mL

2.78mL

1.39mL

27.83mL

5.57mL

2.78mL
参考文献

[1]Seol HS, et al. Loss of miR-100 and miR-125b results in cancer stem cell properties through IGF2 upregulation in hepatocellular carcinoma. Sci Rep. 2020 Dec 8;10(1):21412.