Danshensu

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Chemical Structure| 76822-21-4 同义名 : Salvianic acid A; Dan shen suan A
CAS号 : 76822-21-4
货号 : A124609
分子式 : C9H10O5
纯度 : 99%+
分子量 : 198.173
MDL号 : MFCD09038703
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

H2O: 5 mg/mL(25.23 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 Danshensu, an active ingredient of Salvia miltiorrhiza, shows wide cardiovascular benefit by activating Nrf2 signaling pathway. DSS (Danshensu) significantly decreased the level of the marker enzymes (creatine kinase and lactate dehydrogenase) from the coronary effluents and myocardial infarction size. This could markedly contribute to the recovery of cardiac function after I/R (ischemia reperfusion) injury. DSS also had ROS scavenging activity and boosted endogenous antioxidants such as SOD, CAT, MDA, GSH-PX and HO-1 activities by activating nuclear factor erythroid-2-related factor 2 (Nrf2) signaling pathway which was mediated by Akt and ERK1/2 in western blot analysis[3]. Acute treatment with a single dose of danshensu in rats with normal tHcy (plasma total homocysteine) did not change plasma tHcy. In contrast, danshensu significantly lowered tHcy in rats with elevated tHcy[4]. Danshensu significantly decreased the right ventricle systolic pressure, the right ventricle hypertrophy and pulmonary vascular remodeling index in hypoxic pulmonary hypertension rats. Danshensu also reduced the increased expression of transforming growth factor-β and phosphorylation of smad3 in pulmonary arteries in hypoxic pulmonary hypertension rats. In vitro, danshensu inhibited the hypoxia- or transforming growth factor-β-induced proliferation of primary pulmonary artery smooth muscle cells[5].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

5.05mL

1.01mL

0.50mL

25.23mL

5.05mL

2.52mL

50.46mL

10.09mL

5.05mL
参考文献

[1]Yin Y, Guan Y, et al. Cardioprotective effect of Danshensu against myocardial ischemia/reperfusion injury and inhibits apoptosis of H9c2 cardiomyocytes via Akt and ERK1/2 phosphorylation. Eur J Pharmacol. 2013 Jan 15;699(1-3):219-26.

[2]Li H, Xie YH, et al. Cardioprotective effect of paeonol and danshensu combination on isoproterenol-induced myocardial injury in rats. PLoS One. 2012;7(11):e48872.

[3]Yu J, Wang L, Akinyi M, et al. Danshensu protects isolated heart against ischemia reperfusion injury through activation of Akt/ERK1/2/Nrf2 signaling. Int J Clin Exp Med. 2015;8(9):14793-14804. Published 2015 Sep 15

[4]Cao Y, Chai JG, Chen YC, et al. Beneficial effects of danshensu, an active component of Salvia miltiorrhiza, on homocysteine metabolism via the trans-sulphuration pathway in rats. Br J Pharmacol. 2009;157(3):482-490

[5]Zhang N, Dong M, Luo Y, Zhao F, Li Y. Danshensu prevents hypoxic pulmonary hypertension in rats by inhibiting the proliferation of pulmonary artery smooth muscle cells via TGF-β-smad3-associated pathway. Eur J Pharmacol. 2018;820:1-7