产品说明书
Xylometazoline HCl
 |
同义名 : | Xylometazoline (hydrochloride);Xylometazoline hydrochloride |
| CAS号 : | 1218-35-5 | |
| 货号 : | A124255 | |
| 分子式 : | C16H25ClN2 | |
| 纯度 : | 97% | |
| 分子量 : | 280.836 | |
| MDL号 : | MFCD00238707 | |
| 存储条件： |
粉末 Inert atmosphere,Room Temperature 液体 -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : |
DMSO: 25 mg/mL(89.02 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO H2O: 50 mg/mL(178.04 mM)，配合低频超声助溶 |
|
| 动物实验配方： |
PO 0.5% CMC-Na 50 mg/mL suspension |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Xylometazoline hydrochloride is used as nasal mucosa decongesting α-adrenoceptor agonists during a common cold[2]. Xylometazoline is an effective and well-tolerated decongestant nasal spray that significantly relieved nasal congestion compared with placebo in the common cold and provided long-lasting relief with just 1 spray, helping patients to breathe more easily for a longer period of time[3]. Using the decongestant efficacy provided by xylometazoline HCl(Hydrochloride) and the effectiveness to reduce viral infection accomplished by iota-carrageenan can combine into a new product[4]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT01971762 | - | Completed | - | Spain ... 展开 >> Hospital de Puerto Real Puerto Real, Cádiz, Spain Hospital Costa del Sol Marbella, Málaga, Spain Hospital de Torrecárdenas Almería, Spain Hospital de barcelona - SCIAS Barcelona, Spain Hospital de Cruces Bilbao, Spain Hospital Puerta del Mar Cádiz, Spain Hospital Reina Sofía Córdoba, Spain Hospital Virgen de las Nieves Granada, Spain Hospital Juan Ramón Jiménez Huelva, Spain Hospital de San Pedro Logroño, Spain Hospital de la Arrixaca Murcia, Spain Hospital Carlos Haya Málaga, Spain Hospital Virgen de la Victoria Málaga, Spain Hospital de Valdecillas Santander, Spain Hospital Universitario Virgen de la Macarena Sevilla, Spain Hospital Virgen de Valme Sevilla, Spain 收起 << | |
| NCT03323684 | Laparoscopic Cholecystectomy | Not Applicable | Completed | - | Egypt ... 展开 >> Mansoura University, Faculty of Medicine Mansourah, DK, Egypt, 050 Mansoura University Mansourah, DK, Egypt, 050 收起 << |
| NCT01819597 | Intracranial Arterial Stenosis... 展开 >> Intracranial Atherosclerosis Ischemic Stroke Cerebral Angiogenesis 收起 << | Phase 2 | Recruiting | June 2018 | United States, California ... 展开 >> Cedars Sinai Medical Center Recruiting Los Angeles, California, United States, 90048 Contact: Nestor R Gonzalez, MD, FAHA 310-423-0783 nestor.gonzalez@cshs.org Contact: Antoinette Anderson 310-423-0783 antoinette.anderson@cshs.org Principal Investigator: Nestor R Gonzalez, MD Sub-Investigator: Jeffrey Saver, MD Sub-Investigator: Patrick Lyden, MD Sub-Investigator: Konrad Schlick, MD Sub-Investigator: Shlee Song, MD Sub-Investigator: Michael Alexander, MD Sub-Investigator: Wouter Schievink, MD Sub-Investigator: Oana Dumitrascu, MD 收起 << |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
3.56mL 0.71mL 0.36mL |
17.80mL 3.56mL 1.78mL |
35.61mL 7.12mL 3.56mL |
| 参考文献 |
|---|