产品说明书

Isovanillin

Print
Chemical Structure| 621-59-0 同义名 : 3-羟基-4-甲氧基苯甲醛 ;3-Hydroxy-4-methoxybenzaldehyde;5-Formylguaiacol;3-Hydroxy-p-anisaldehyde
CAS号 : 621-59-0
货号 : A122974
分子式 : C8H8O3
纯度 : 98%
分子量 : 152.147
MDL号 : MFCD00003369
存储条件：

粉末 Keep in dark place,Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(690.12 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Isovanicaline widely exist in many plants, such as Pycnocycla spinosa. P [1] . In vitro studies, isovanicaline, combined with curcumin and harmine, could suppress the proliferation of head and neck squamous cells by inhibiting the signaling pathway of EGFR, ERK1/2, and AKT [2] . In vivo studies, it was found that the extract of arum palaestinum, containing high level of isovanicaline, had the ability of inhibiting the cell proliferation of xenografted prostate tumors in mice, while without signs of toxicity for non-cancer tissue [3] . Besides this, isovanicaline could contribute to the detention of onset of diarrhoea and the reduction of wet defecation induced by castor oil and MgSO4 in mice [1] .
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

6.57mL

1.31mL

0.66mL

32.86mL

6.57mL

3.29mL

65.72mL

13.14mL

6.57mL
参考文献

[1]Sadraei H, Ghanadian M, et al. Antidiarrheal activities of isovanillin, iso-acetovanillon and Pycnocycla spinosa Decne ex.Boiss extract in mice. Res Pharm Sci. 2014;9(2):83-9.

[2]Vishwakarma V, New J, et al. Potent Antitumor Effects of a Combination of Three Nutraceutical Compounds. Sci Rep. 2018;8(1):12163.

[3]Cole C, Burgoyne T, et al. Arum Palaestinum with isovanillin, linolenic acid and β-sitosterol inhibits prostate cancer spheroids and reduces the growth rate of prostate tumors in mice. BMC Complement Altern Med. 2015.