PARP-1-IN-2

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Chemical Structure| 684234-55-7 同义名 : -
CAS号 : 684234-55-7
货号 : A1227418
分子式 : C22H15Cl2N3O2
纯度 : 99%+
分子量 : 424.279
MDL号 : N/A
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 85 mg/mL(200.34 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 PARP-1-IN-2 is a potent, BBB-penetrating PARP1 inhibitor with an IC50 of 149 nM, demonstrating significant anti-proliferative effects and inducing apoptosis in A549 lung adenocarcinoma cells[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.36mL

0.47mL

0.24mL

11.78mL

2.36mL

1.18mL

23.57mL

4.71mL

2.36mL
参考文献

[1]Almahli H, et al. Development of novel synthesized phthalazinone-based PARP-1 inhibitors with apoptosis inducing mechanism in lung cancer. Bioorg Chem. 2018 Apr;77:443-456.