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Lenalidomide-OH

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Chemical Structure| 1416990-08-3 同义名 : -
CAS号 : 1416990-08-3
货号 : A1220561
分子式 : C13H12N2O4
纯度 : 97%
分子量 : 260.245
MDL号 : MFCD31794971
存储条件：

粉末 Inert atmosphere,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 12 mg/mL(46.11 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Lenalidomide-OH is a derivative of the cereblon (CRBN) ligand Lenalidomide, designed for E3 ubiquitin ligase recruitment, facilitating the binding of CRBN protein. It serves as a component in PROTACs, like the PROTAC BTK degrader SJF620, by linking to the ligand for targeted protein degradation[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.84mL

0.77mL

0.38mL

19.21mL

3.84mL

1.92mL

38.43mL

7.69mL

3.84mL
参考文献

[1]Jaime-Figueroa S, et al. Design, synthesis and biological evaluation of Proteolysis Targeting Chimeras (PROTACs) as a BTK degraders with improved pharmacokinetic properties. 2020 Feb 1;30(3):126877.