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TLR7/8 Agonist 1

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Chemical Structure| 1258457-59-8 同义名 : -
CAS号 : 1258457-59-8
货号 : A1219082
分子式 : C22H25N5
纯度 : 99%+
分子量 : 359.467
MDL号 : MFCD34601662
存储条件：

粉末 Keep in dark place,Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 10 mg/mL(27.82 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 TLR7/8 Agonist 1 has significant immunostimulatory activity. TLR7/8 Agonist 1 is a flexible precursor that can be covalently linked to fluorophores without significant loss of activity. TLR7/8 Agonist 1 can be directly covalently linked to commercial fluorescein isothiocyanate and rhodamine B isothiocyanate[1] . TLR7/8 Agonist 1 is agonist potent against human TLR7/8 with IC50 values of 50 nM and 55 nM, respectively[2] .
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.78mL

0.56mL

0.28mL

13.91mL

2.78mL

1.39mL

27.82mL

5.56mL

2.78mL
参考文献

[1]Shukla NM, et al. Syntheses of fluorescent imidazoquinoline conjugates as probes of Toll-like receptor 7. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6384-6.

[2]Beesu M, et al. Structure-Based Design of Human TLR8-Specific Agonists with Augmented Potency and Adjuvanticity. J Med Chem. 2015 Oct 8;58(19):7833-49.