Eupatilin

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Chemical Structure| 22368-21-4 同义名 : 异泽兰黄素 ;NSC 122413
CAS号 : 22368-21-4
货号 : A121685
分子式 : C18H16O7
纯度 : 99%+
分子量 : 344.315
MDL号 : MFCD13194819
存储条件：

Pure form Keep in dark place,Sealed in dry,Store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 35 mg/mL(101.65 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Eupatilin (5,7-dihydroxy-3',4',6-trimethoxyflavone) is the main lipophilic flavonoid obtained from the Artemisia species. Eupatilin has been reported to have anti-apoptotic, anti-oxidative and anti-inflammatory activities. Eupatilin increases transcriptional activity and expression of peroxisome proliferator-activated receptor α (PPARα) in a keratinocyte cell line and acts as an agonist of PPARα. PPARα agonists ameliorate atopic dermatitis (AD) and restore the skin barrier function. Eupatilin (10, 30, 100 μM) suppresses IL-4 expression and degranulation in RBL-2H3 cells[3]. Eupatilin inhibits TNFα(tumor necrosis factor-alpha)-induced MMP-2/-9 expression by suppressing NF-κB and MAPK⁄AP-1 pathways via PPARα[4]. Eupatilin protected against H2O2-induced oxidative stress and apoptosis through the activation of PI3K/Akt signaling pathway in ARPE-19 cells[5]. Eupatilin can inhibit IL-1β-induced apoptosis via sestrin2-dependent autophagy in chondrocytes[6]. Eupatilin alleviated LPS(lipopolysaccharide)-induced ALI (acute lung injury) through inhibiting inflammation and oxidative stress in a concentration-dependent way, which was likely to be closely related with the activation of PPAR-alpha[7].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.90mL

0.58mL

0.29mL

14.52mL

2.90mL

1.45mL

29.04mL

5.81mL

2.90mL
参考文献

[1]Jung Y, Kim JC, et al. Eupatilin, an activator of PPARα, inhibits the development of oxazolone-induced atopic dermatitis symptoms in Balb/c mice. Biochem Biophys Res Commun. 2018;496(2):508-514

[2]Jeong EK, Jang HJ, et al. Protective effect of eupatilin against renal ischemia-reperfusion injury in mice. Transplant Proc. 2015 Apr;47(3):757-62.

[3]Jung Y, Kim JC, Park NJ, Bong SK, Lee S, Jegal H, Jin LT, Kim SM, Kim YK, Kim SN. Eupatilin, an activator of PPARα, inhibits the development of oxazolone-induced atopic dermatitis symptoms in Balb/c mice. Biochem Biophys Res Commun. 2018 Feb 5;496(2):508-514

[4]Jung Y, Kim JC, Choi Y, Lee S, Kang KS, Kim YK, Kim SN. Eupatilin with PPARα agonistic effects inhibits TNFα-induced MMP signaling in HaCaT cells. Biochem Biophys Res Commun. 2017 Nov 4;493(1):220-226

[5]Du L, Chen J, Xing YQ. Eupatilin prevents H2O2-induced oxidative stress and apoptosis in human retinal pigment epithelial cells. Biomed Pharmacother. 2017 Jan;85:136-140

[6]Lou Y, Wu J, Liang J, Yang C, Wang K, Wang J, Guo X. Eupatilin protects chondrocytes from apoptosis via activating sestrin2-dependent autophagy. Int Immunopharmacol. 2019 Oct;75:105748

[7]Liu H, Hao J, Wu C, Liu G, Wang X, Yu J, Liu Y, Zhao H. Eupatilin Alleviates Lipopolysaccharide-Induced Acute Lung Injury by Inhibiting Inflammation and Oxidative Stress. Med Sci Monit. 2019 Nov 4;25:8289-8296