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MALAT1-IN-1

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Chemical Structure| 827327-28-6 同义名 : -
CAS号 : 827327-28-6
货号 : A1216706
分子式 : C19H21N3O2
纯度 : 98%+
分子量 : 323.389
MDL号 : MFCD06011226
存储条件：

粉末 Keep in dark place,Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(371.07 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Metastasis Associated Lung Adenocarcinoma Transcript 1 (MALAT1) is a nuclear enriched long non-coding RNA that is generally overexpressed in patient tumors and metastases[1]. MALAT1 played a role in regulating cancer process by functioning as a competing endogenous RNA. Silencing MALAT1 could effectively decrease the expression level of SOX9, thus suppress cell viability and metastasis. Down-regulated MALAT1 could induce resistance of G1 phase in cell cycle, and facilitation of colorectal cancer cell apoptosis.[2]. MALAT1-IN-1 is a potent and highly specific MALAT1 inhibitor. MALAT1-IN-1 modulated Malat1 downstream genes in a dose-dependent manner without affecting the expression of nuclear enriched abundant transcript 1 (Neat1).[3]. MALAT1-IN-1 has effectively prevented the pathological remodeling of the aortic wall induced by Angll infusion in the model of AAA mice experiment. The inhibitor can protect the aorta based on three aspects, prevention, inhibition, and reversal of AAA, and it has significant clinical value in therapeutic strategies for AAA[4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.09mL

0.62mL

0.31mL

15.46mL

3.09mL

1.55mL

30.92mL

6.18mL

3.09mL
参考文献

[1]Gayatri Arun,et al. MALAT1 long non-coding RNA and breast cancer. RNA Biol. 2019. 16(6), 860-863.

[2]Yuanlin Xu,et al. The effects of lncRNA MALAT1 on proliferation, invasion and migration in colorectal cancer through regulating SOX9. Mol Med. 2018. 24(1), 52.

[3]Abulwerdi FA, et al. Selective Small-Molecule Targeting of a Triple Helix Encoded by the Long Noncoding RNA, MALATACS Chem Biol. 2019. 14(2), 223-235.

[4]Yu, L., et al. An intersegmental single- cell profile reveals aortic heterogeneity and identifies a novel Malat1+ vascular smooth muscle subtype involved in abdominal aortic aneurysm formation. Signal Transduction and Targeted Therapy. 2022. 7, 126.