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Sigma-1 receptor antagonist 3

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Chemical Structure| 1639220-17-9 同义名 : -
CAS号 : 1639220-17-9
货号 : A1216660
分子式 : C19H23ClFN3O
纯度 : 99%+
分子量 : 363.857
MDL号 : -
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 12 mg/mL(32.98 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Sigma-1 receptor antagonist 3, a potent and selective antagonist of the Sigma-1 (σ1) receptor, exhibits a dissociation constant (Ki) of 1.14 nM. It also inhibits the Human Ether-a-go-go-Related Gene (hERG) channel with an IC50 of 1.54 μM, indicating potential for neuropathic pain treatment[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.75mL

0.55mL

0.27mL

13.74mL

2.75mL

1.37mL

27.48mL

5.50mL

2.75mL
参考文献

[1]Lan Y, et al. Synthesis and biological evaluation of novel sigma-1 receptor antagonists based on pyrimidine scaffold as agents for treating neuropathic pain. J Med Chem. 2014 Dec 26;57(24):10404-23.