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ML192

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Chemical Structure| 460331-61-7 同义名 : CID-1434953
CAS号 : 460331-61-7
货号 : A1210826
分子式 : C20H22N4O2S
纯度 : 97%
分子量 : 382.479
MDL号 : MFCD03127624
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(274.52 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 ML192 is a selective ligand antagonist of GPR55. ML192 inhibited L-α lysophosphatidylinositol or ML186-induced β-arrestin trafficking with IC50 values of 0.70 µM and 0.29 µM, respectively. ML192 significantly inhibited ERK1 in U2OS cells expressing GPRSS. ML192 significantly inhibited the phosphorylation of ERK1/2 in U2OS cells expressing GPRSS, with an IC50 value of 1.1 µM. ML192 reduced PKCβII translocation in wild-type GPR55 receptor cells at concentrations of 10, 30, and 100 µM[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.61mL

0.52mL

0.26mL

13.07mL

2.61mL

1.31mL

26.15mL

5.23mL

2.61mL
参考文献

[1]Kotsikorou E, et al. Identification of the GPR55 antagonist binding site using a novel set of high-potency GPR55 selective ligands. Biochemistry. 2013 Dec 31;52(52):9456-69.