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Gavestinel sodium salt

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Chemical Structure| 153436-38-5 同义名 : GV 150526A;Gavestinel (sodium salt)
CAS号 : 153436-38-5
货号 : A1209780
分子式 : C18H11Cl2N2NaO3
纯度 : 98%
分子量 : 397.187
MDL号 : MFCD00923984
存储条件：

粉末 Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(264.36 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Gavestinel sodium salt is a potent, selective, orally active and non-competitive NMDA receptor antagonist. Gavestinel sodium salt binds to the glycine site of the NMDA receptor with a pKi of 8.5. Gavestinel sodium salt is used in acute ischaemic stroke Gavestinel sodium salt can be used in acute ischaemic stroke studies[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.52mL

0.50mL

0.25mL

12.59mL

2.52mL

1.26mL

25.18mL

5.04mL

2.52mL
参考文献

[1]Fabio RD, et, al. Substituted indole-2-carboxylates as in vivo potent antagonists acting as the strychnine-insensitive glycine binding site. J Med Chem. 1997 Mar 14;40(6):841-50.