生物活性 | |||
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描述 | SB-657510 is a selective urotensin II receptor antagonist. The Ki values for human, monkey, cat, rat and mouse receptors are 61, 17, 30, 65 and 56 nM, respectively. SB-657510 inhibits UII-induced up-regulation of inflammatory mediators (e.g., adhesion molecules, cytokines, and tissue factors in human vascular endothelial cells), thereby exerting anti-inflammatory effects]1][2].SB-657510 significantly blocked the UII-induced increase in adhesion between U937 cells and EA.hy926 cells. At a concentration of 1 μM for 0.5-8 hours, SB-657510 blocked UII-induced tissue factor expression in endothelial cells[1].SB-657510 inhibited [Ca2+]i migration induced by 10 nM hU-II in the concentration range of 1-10000 nM with an IC50 value of 180 nM[2]. |
实验方案 | |||
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1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
1.98mL 0.40mL 0.20mL |
9.89mL 1.98mL 0.99mL |
19.77mL 3.95mL 1.98mL |
参考文献 |
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