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Qc1

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Chemical Structure| 403718-45-6 同义名 : -
CAS号 : 403718-45-6
货号 : A1209600
分子式 : C23H16F3N3O2S
纯度 : 99%+
分子量 : 455.452
MDL号 : -
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 60 mg/mL(131.74 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Qc1 is a reversible, non-competitive threonine dehydrogenase (TDH) inhibitor. Qc1 blocks the charging of tetrahydrofolate. Qc1 prevents the catabolism of threonine dehydrogenase from threonine to acetyl-CoA and glycine. Qc1 is used in the study of metabolic diseases [1][2]. Qc1 enhances autophagy activity in ES cells at a concentration of 10 μM for 2-24 h. A large proportion of the total LC3 protein is in the LC3-I (cytoplasmic) form, whereas after 16 hours of Qc1 action, most of the LC3 is converted to the LC3-II (lipid-modified) form [2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.20mL

0.44mL

0.22mL

10.98mL

2.20mL

1.10mL

21.96mL

4.39mL

2.20mL
参考文献

[1]Wang J, et al. Metabolic specialization of mouse embryonic stem cells. Cold Spring Harb Symp Quant Biol. 2011;76:183-193.

[2]Alexander PB, et al. Targeted killing of a mammalian cell based upon its specialized metabolic state. Proc Natl Acad Sci U S A. 2011;108(38):15828-15833.