HSP27 inhibitor J2

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Chemical Structure| 2133499-85-9 同义名 : J2
CAS号 : 2133499-85-9
货号 : A1196115
分子式 : C13H12O4S
纯度 : 99%+
分子量 : 264.297
MDL号 : MFCD32201069
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 18 mg/mL(68.11 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 The HSP27 inhibitor J2 disrupts normal HSP27 dimer formation and prevents the formation of large HSP27 polymers, reducing its chaperone function and cellular protection. J2 significantly boosts the antiproliferative effects of 17-AAG and increases sensitivity to cisplatin-induced inhibition of lung cancer cell growth[1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.78mL

0.76mL

0.38mL

18.92mL

3.78mL

1.89mL

37.84mL

7.57mL

3.78mL
参考文献

[1]Hwang SY, et al. Synthesis and biological effect of chrom-4-one derivatives as functional inhibitors of heat shockprotein 27. Eur J Med Chem. 2017 Oct 20;139:892-900.

[2]Younghwa Na, et al. Methods for treating pulmonary fibrosis using chromenone derivatives.