产品说明书

H2L 5765834

Print
Chemical Structure| 420841-84-5 同义名 : -
CAS号 : 420841-84-5
货号 : A1193895
分子式 : C21H12N2O7
纯度 : 98%+
分子量 : 404.329
MDL号 : MFCD01137741
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 250 mg/mL(618.31 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 H2L 5765834 acts as an inhibitor against the lysophosphatidic acid receptors LPA1, LPA3, and LPA5, demonstrating IC50 values of 94, 752, and 463 nM, respectively[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.47mL

0.49mL

0.25mL

12.37mL

2.47mL

1.24mL

24.73mL

4.95mL

2.47mL
参考文献

[1]Williams JR, et, al. Unique ligand selectivity of the GPR92/LPA5 lysophosphatidate receptor indicates role in human platelet activation. J Biol Chem. 2009 Jun 19; 284(25): 17304-19.

[2]Bae GH, et, al. Lysophosphatidic acid protects against acetaminophen-induced acute liver injury. Exp Mol Med. 2017 Dec 8; 49(12): e407.