TC LPA5 4

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Chemical Structure| 1393814-38-4 同义名 : -
CAS号 : 1393814-38-4
货号 : A1193894
分子式 : C23H23ClN2O3
纯度 : 99%
分子量 : 410.893
MDL号 : MFCD26792575
存储条件：

Pure form Keep in dark place,Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 60 mg/mL(146.02 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 TC LPA5 4 is an LPA5 (GPR92)-specific non-lipid antagonist. TC LPA5 4 inhibited LPA-induced aggregation of isolated human platelets (LPA5-RH7777 cell line) with an IC50 of 800 nM. TC LPA5 4 showed selectivity for LPA5 among 80 targets screened[1].TC LPA5 4 significantly inhibited the proliferation of thyroid cancer cells CGTH-W3, TPC-1, B-CAPAP and BHT101, with IC50s of 103.0 μM, 84.9 μM, 55.9 μM and 57.17 μM, respectively. At concentration of 5 μM for 24 hours, TC LPA5 4 significantly inhibited the migration of CGTH-W3 and TPC-1 cells stimulated by LPA, with an inhibition rate of about 30%. As B-CPAP and BHT101 cells expressed higher LPAR5 mRNA, TC LPA5 4 inhibited the proliferation of these two cell lines, with IC50s of 55.9 μM and 57.17 μM, whereas, as CGTH-W3 and TPC-1 cells expressed lower LPAR5 mRNA, TC LPA5 4 had different anti-tumour activities, with IC50s of 103.0 μM and 84.9 μM, respectively[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.43mL

0.49mL

0.24mL

12.17mL

2.43mL

1.22mL

24.34mL

4.87mL

2.43mL
参考文献

[1]Kozian DH, et al. Selective non-lipid modulator of LPA5 activity in human platelets. Bioorg Med Chem Lett. 2012;22(16):5239-5243.

[2]Zhao WJ, et al. LPAR5 promotes thyroid carcinoma cell proliferation and migration by activating class IA PI3K catalytic subunit p110β. Cancer Sci. 2021;112(4):1624-1632.