产品说明书
Tenofovir Disoproxil
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同义名 : | Bis(POC)-PMPA;GS 4331 |
| CAS号 : | 201341-05-1 | |
| 货号 : | A119233 | |
| 分子式 : | C19H30N5O10P | |
| 纯度 : | 98% | |
| 分子量 : | 519.443 | |
| MDL号 : | MFCD00952920 | |
| 存储条件： |
粉末 Keep in dark place,Inert atmosphere,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 40 mg/mL(77.01 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Tenofovir exhibits cytotoxicity in HK-2 cells, with IC50 values of 9.21 and 2.77 μM at 48 and 72 hours in the MTT assay, respectively. It reduces ATP levels and increases oxidative stress and protein carbonylation within the concentration range of 3.0 to 28.8 μM in HK-2 cells. Additionally, Tenofovir triggers apoptosis via mitochondrial damage in HK-2 cells [1]. Tenofovir and M48U1, each formulated in 0.25% HEC, collectively inhibit the replication of R5-tropic HIV-1BaL and X4-tropic HIV-1IIIb in activated PBMCs, as well as various laboratory strains and patient-derived HIV-1 isolates. The combined formulation of M48U1 and tenofovir in 0.25% HEC demonstrates synergistic antiretroviral activity against R5-tropic HIV-1BaL infection without PBMC toxicity [2]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT02287857 | Chronic Hepatitis B | Not Applicable | Recruiting | October 2019 | China, Beijing ... 展开 >> Beijing Ditan Hospital Capital Medical University Recruiting Beijing, Beijing, China, 100015 Contact: Xiao hua Hao, doctor 13466590802 xiaohualuck@sina.com Peking University First Hospital Recruiting Beijing, Beijing, China, 100034 Contact: Li qin Yu, doctor 010-66119025 jgbgs090101@126.com Peking University People's Hospital Recruiting Beijing, Beijing, China, 100044 Contact: Hao Wang, doctor 010-88325988 jgbgs090101@126.com Beijing You An Hospital, Capital Medical University Recruiting Beijing, Beijing, China, 100069 Contact: Mei xia Wang, doctor 010-83997322 youangcp@163.com China, Chongqing First Affiliated Hospital, Third Military Medical University Recruiting Chongqing, Chongqing, China, 400039 Contact: Yong chuan Chen, doctor 13883405537 zwmcyc@163.com China, Guangdong Third Affiliated Hospital of Sun Yat-sen Recruiting Guangzhou, Guangdong, China, 510630 Contact: Qian Huang, doctor 02085253153 sankyk@163.com China, Henan Henan Provincial People's Hospital Recruiting Zhengzhou, Henan, China, 450003 Contact: Xiu Jin, doctor 13526660319 First Affiliated Hospital of Zhengzhou University Recruiting Zhengzhou, Henan, China, 450052 Contact: Juan Li, doctor 13526506270 China, Jiangsu The Second Hospital of Nanjing Recruiting Nanjing, Jiangsu, China, 210003 Contact: Yu Pan, doctor 13814099474 First Affiliated Hospital of Nanjing Medical University Recruiting Nanjing, Jiangsu, China Contact: Xu Huang, doctor 02568136360 jsphkj@163.com China, Shanghai Ruijin Hospital Shanghai Jiaotong University School of Medicine Recruiting Shanghai, Shanghai, China, 200025 Contact: Yi feng Wang, doctor 02154661789 ruijin_gcp@126.com Huashan Hospital, Fudan University Recruiting Shanghai, Shanghai, China, 200040 Contact: Fei Dong, doctor 02152888041 Shanghai Public Health Clinical Center Recruiting Shanghai, Shanghai, China, 201508 Contact: Na Li, doctor 18916082023 lina40125@shaphc.org China, Sichuan West China Hospital of Sichuan University Recruiting Chengdou, Sichuan, China, 610041 Contact: Juan Liao, doctor 15828323384 hxcrgcp@163.com China, Zhejiang First Affiliated Hospital of Zhejiang University School of Medicine Recruiting Hangzhou, Zhejiang, China Contact: Li hua Wu, doctor 13819195192 收起 << |
| NCT03251144 | HIV/AIDS Anti... 展开 >>viral Toxicity Antiviral Drug Adverse Reaction Mitochondrial Alteration 收起 << | Phase 1 Phase 2 | Recruiting | July 31, 2020 | United States, California ... 展开 >> UCLA CARE Center Recruiting Los Angeles, California, United States, 90035 Contact: Theodoros Kelesidis, MD, PhD, Msc 310-825-7225 tkelesidis@mednet.ucla.edu 收起 << |
| NCT03236610 | Proportion of Patients With a ... 展开 >>Sustained Virological Response (Serum HBV DNA <20 IU/mL) at Week 48 收起 << | Phase 3 | Recruiting | June 30, 2019 | Korea, Republic of ... 展开 >> Uijeongbu St. Mary Hospital Recruiting Uijongbu, Korea, Republic of Contact: Chang Wook Kim 82318203997 cwkim@catholic.ac.kr 收起 << |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
1.93mL 0.39mL 0.19mL |
9.63mL 1.93mL 0.96mL |
19.25mL 3.85mL 1.93mL |
| 参考文献 |
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