(E/Z)-Necrosulfonamide

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Chemical Structure| 432531-71-0 同义名 : -
CAS号 : 432531-71-0
货号 : A1191953
分子式 : C18H15N5O6S2
纯度 : 98%+
分子量 : 461.472
MDL号 : MFCD02370191
存储条件：

Pure form Keep in dark place,Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 (E/Z)-Necrosulfonamide, a racemic mixture of Necrosulfonamide, serves as an inhibitor of necroptosis by specifically targeting the mixed lineage kinase domain-like protein (MLKL). It hinders the MLKL-RIP1-RIP3 necrosome complex from engaging with downstream effectors. MLKL is deemed a vital target of RIP3 during necrosis initiation[1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.17mL

0.43mL

0.22mL

10.83mL

2.17mL

1.08mL

21.67mL

4.33mL

2.17mL
参考文献

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]Sun L, et al. Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase. Cell. 2012;148(1-2):213-227.