产品说明书
Acyclovir
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同义名 : | 阿昔洛韦 ;Aciclovir;Acycloguanosine;NSC 645011;ACV;BW 248U |
| CAS号 : | 59277-89-3 | |
| 货号 : | A118981 | |
| 分子式 : | C8H11N5O3 | |
| 纯度 : | 98% | |
| 分子量 : | 225.2 | |
| MDL号 : | MFCD00057880 | |
| 存储条件： |
粉末 Keep in dark place,Inert atmosphere,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 50 mg/mL(222.02 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Acyclovir (aciclovir) is a nucleoside antiviral drug with antiviral activity in vitro against members of the herpes group of DNA viruses. As an established treatment of herpes simplex infection, intravenous, oral and to a lesser extent topical formulations of acyclovir provide significant therapeutic benefit in genital herpes simplex and recurrent orofacial herpes simplex. Ophthalmic application of 3% acyclovir ointment rapidly heals herpetic dendritic corneal ulcers and superficial herpetic keratitis[3]. Acyclovir is a selective antiherpes agent. Its selective activity is by exploitation of differences between the herpes-specific and host cell enzymes. In immunocompromised patients, acyclovir is effective for the prophylaxis and therapy of herpes simplex virus infections and for the treatment of herpes zoster and varicella. In nonimmunocompromised patients, acyclovir is beneficial in the therapy of herpes keratoconjunctivitis and in the therapy of genital herpes, with maximal benefit seen in those patients who have primary genital herpes[4]. Acyclovir (aciclovir) is a nucleoside analogue antiviral drug related to cytarabine, idoxuridine, trifluridine and vidarabine. Orally and intravenously administered acyclovir were beneficial in initial genital herpes infections, and oral therapy shortened the duration of recurrent infections by 1 to 2 days but did not ameliorate pain[5]. | ||
| 细胞研究 | |||||
|---|---|---|---|---|---|
| 细胞系 | 浓度 | 检测类型 | 检测时间 | 活动说明 | 数据源 |
| African green monkey Vero 76 cells | Cytotoxicity assay | 48-96 h | Cytotoxicity against African green monkey Vero 76 cells assessed as cell viability after 48 to 96 hrs by crystal violet staining, CC50=13 μM | 26119992 | |
| african green monkey Vero cells | Function assay | 48 h | Antiviral activity against HSV2 strain 333 infected in african green monkey Vero cells assessed as inhibition of cytopathic effect after 48 hrs by plaque reduction assay, EC50=1.87 μM | 22704890 | |
| BSC-1 cells | Function assay | Antiviral activity of the compound was evaluated against the Herpes simplex virus type-1 in BSC-1 cells, IC50=2.6 μM | 2913300 | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT03443869 | CMV Disease | Phase 3 | Recruiting | September 19, 2021 | - |
| NCT02157090 | Herpes Simplex Labialis | Not Applicable | Completed | - | Germany ... 展开 >> University Hospital Carl Gustav Carus at the Technische Universität Dresden Dresden, Saxony, Germany, 01307 收起 << |
| NCT00343278 | Virus Diseases | Phase 4 | Completed | - | - |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
4.44mL 0.89mL 0.44mL |
22.20mL 4.44mL 2.22mL |
44.40mL 8.88mL 4.44mL |
| 参考文献 |
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