SIRT-IN-2

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Chemical Structure| 1431411-66-3 同义名 : -
CAS号 : 1431411-66-3
货号 : A1177281
分子式 : C15H21N5O3S2
纯度 : 99%
分子量 : 383.489
MDL号 : MFCD28386340
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 60 mg/mL(156.46 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 SIRT-IN-2 is a highly potent truncated pan-inhibitor targeting SIRT1/2/3, with IC50 values of 4, 4, and 7 μM, respectively. It binds uniformly in the catalytic active site, affecting both the nicotinamide C-pocket and the acetyl lysine substrate channel[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.61mL

0.52mL

0.26mL

13.04mL

2.61mL

1.30mL

26.08mL

5.22mL

2.61mL
参考文献

[1]Disch JS, et al. Discovery of thieno[3,2-d]pyrimidine-6-carboxamides as potent inhibitors of SIRT1, SIRT2, and SIRT3. J Med Chem. 2013 May 9;56(9):3666-79.