PK68

产品说明书

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Chemical Structure| 2173556-69-7 同义名 : -
CAS号 : 2173556-69-7
货号 : A1177185
分子式 : C22H24N4O3S
纯度 : 99%+
分子量 : 424.516
MDL号 : -
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 30 mg/mL(70.67 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 PK68, a potent and selective oral type II inhibitor of receptor-interacting kinase 1 (RIPK1) with an IC50 of ~90 nM, effectively inhibits RIPK1-dependent necroptosis. It significantly mitigates TNF-induced systemic inflammatory response syndrome and is applicable in studying inflammatory disorders and cancer metastasis [1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.36mL

0.47mL

0.24mL

11.78mL

2.36mL

1.18mL

23.56mL

4.71mL

2.36mL
参考文献

[1]Jue Hou, et al. Discovery of potent necroptosis inhibitors targeting RIPK1 kinase activity for the treatment of inflammatory disorder and cancer metastasis. Cell Death Dis. 2019 Jun 24;10(7):493.