产品说明书
AZ084
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同义名 : | - |
| CAS号 : | 929300-19-6 | |
| 货号 : | A1177059 | |
| 分子式 : | C26H34N4O2 | |
| 纯度 : | 99% | |
| 分子量 : | 434.574 | |
| MDL号 : | MFCD32062782 | |
| 存储条件： |
粉末 Keep in dark place,Sealed in dry,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 250 mg/mL(575.28 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | AZ084 is a potent, selective, allosteric and orally active CCR8 antagonist with a Ki of 0.9 nM [1].AZ084 inhibits the formation of immunologically tolerant pre-metastatic niche (PMN) and metastasis of tumour cells in the lungs through down-regulation of Treg differentiation [1][2].Administered once daily for 4 days at a concentration of 5 μg/mL, AZ084 inhibits the proportion of Treg and reduces CCR8-expressing T cells (cultured ex vivo with LLC-exo MPF CM)[1][2].At concentrations of 0-10 μM, AZ084 inhibited AML, DC and T cells with IC50 values of 1.3 nM, 4.6 nM and 5.7 nM, respectively[2] . | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
2.30mL 0.46mL 0.23mL |
11.51mL 2.30mL 1.15mL |
23.01mL 4.60mL 2.30mL |
| 参考文献 |
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