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DJ-V-159

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Chemical Structure| 2253744-53-3 同义名 : -
CAS号 : 2253744-53-3
货号 : A1176980
分子式 : C24H12F6N4O2
纯度 : 99%+
分子量 : 502.368
MDL号 : -
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 25 mg/mL(49.76 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 DJ-V-159 is an agonist of GPRC6A. DJ-V-159 activates ERK in GPRC6A-transfected HEK-293 cells, but has no effect on non-transfected HEK-293 cells, with potency similar to L-Arg. In addition, DJ-V-159 dose-dependently stimulated cAMP production in HEK-293 cells expressing GPRC6A, with a response at a concentration of 0.2 nM in the culture medium. DJ-V-159 stimulated insulin secretion from mouse MIN-6 cells, increasing the insulin stimulation index (SI), with an effect similar to that of Ocn, a known ligand for GPRC6A[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.99mL

0.40mL

0.20mL

9.95mL

1.99mL

1.00mL

19.91mL

3.98mL

1.99mL
参考文献

[1]Pi M, et al. Computationally identified novel agonists for GPRC6A. PLoS One. 2018 Apr 23;13(4):e0195980.