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AZD3229

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Chemical Structure| 2248003-60-1 同义名 : -
CAS号 : 2248003-60-1
货号 : A1176920
分子式 : C24H26FN7O3
纯度 : 99.55%
分子量 : 479.507
MDL号 : MFCD31807612
存储条件：

粉末 Keep in dark place,Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 40 mg/mL(83.42 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 AZD3229 is a potent pan-KIT mutant inhibitor for the treatment of gastrointestinal mesenchymal tumours. c-KIT was inhibited by AZD3229 with an IC50 value of 223.3 nM[1][2].AZD3229 is a potent pan-KIT mutant inhibitor with potent growth inhibition (GI50=1-50 nM) in different mutant KIT-driven Ba/F3 cell lines[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.09mL

0.42mL

0.21mL

10.43mL

2.09mL

1.04mL

20.85mL

4.17mL

2.09mL
参考文献

[1]Ryu H, et.al. Antitumor Activity of a Novel Tyrosine Kinase Inhibitor AIU2001 Due to Abrogation of the DNA Damage Repair in Non-Small Cell Lung Cancer Cells. Int J Mol Sci. 2019 Sep 24;20(19):4728.

[2]Kettle JG, et al. Discovery of N-(4-{[5-Fluoro-7-(2-methoxyethoxy) quinazolin-4-yl]amino} phenyl)-2-[4-(propan-2-yl)-1 H-1,2,3-triazol-1-yl]acetamide (AZD3229), a Potent Pan-KIT Mutant Inhibitor for the Treatment of Gastrointestinal Stromal Tumors. J Med Chem. 2018 Oct 11;61(19):8797-8810.