产品说明书

NCT-505

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Chemical Structure| 2231079-74-4 同义名 : -
CAS号 : 2231079-74-4
货号 : A1176834
分子式 : C27H28FN5O3S
纯度 : 95%
分子量 : 521.606
MDL号 : MFCD31715429
存储条件：

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(201.3 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 NCT-505 is a potent and selective ALDH1A1 inhibitor with an IC50 value of 7 nM, and weakly inhibits hALDH1A2, hALDH1A3, hALDH2, and hALDH3A1. NCT-505 is a potent and selective ALDH1A1 inhibitor, with an IC50 value of 7 nM, and weakly inhibits the production of hALDH1A2, hALDH1A3, hALDH2, and hALDH3A1. 5-hydroxyprostaglandin dehydrogenase (HPGD) and type-4 hydroxysteroid dehydrogenase (HSD17β4) were not significantly inhibited by NCT-505 (IC50>57 μM). In addition, NCT-505 showed potent cytotoxicity and reduced the viability of OV-90 cells with EC50 values of 2.10-3.92 μM. NCT-505 was also cytotoxic to SKOV-3-TR cells, with IC50s of 1, 3, 10, 20, and 30 μM in a titration assay[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.92mL

0.38mL

0.19mL

9.59mL

1.92mL

0.96mL

19.17mL

3.83mL

1.92mL
参考文献

[1]Yang SM, et al. Discovery of Orally Bioavailable, Quinoline-Based Aldehyde Dehydrogenase 1A1 (ALDH1A1) Inhibitors with Potent Cellular Activity. J Med Chem. 2018 Jun 14;61(11):4883-4903.