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SPP-86

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Chemical Structure| 1357349-91-7 同义名 : -
CAS号 : 1357349-91-7
货号 : A1176675
分子式 : C16H15N5
纯度 : 99%+
分子量 : 277.324
MDL号 : MFCD23379049
存储条件：

粉末 Keep in dark place,Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(378.62 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • PI3K
描述 SPP-86 is a potent, selective, cell-permeable inhibitor of RET with an IC50 value of 8 nM. SPP-86 inhibits RET-induced PI3K/Akt and MAPK signalling and also inhibits RET-induced phosphorylation of Erα receptor in MCF7 cells. At a concentration of less than 10 μM, SPP-86 inhibited MAPK signalling and proliferation in RET/PTC1-expressing TPC1 cells, but not 8505C or C643 cells[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.61mL

0.72mL

0.36mL

18.03mL

3.61mL

1.80mL

36.06mL

7.21mL

3.61mL
参考文献

[1]Alao JP, et al. Selective inhibition of RET mediated cell proliferation in vitro by the kinase inhibitor SPP86. BMC Cancer. 2014 Nov 20;14:853.