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CH7057288

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Chemical Structure| 2095616-82-1 同义名 : -
CAS号 : 2095616-82-1
货号 : A1176610
分子式 : C32H31N3O5S
纯度 : 98%
分子量 : 569.671
MDL号 : MFCD31715415
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 35 mg/mL(61.44 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 CH7057288 is a potent and selective TRK inhibitor. In an intracranial implantation model simulating brain metastases, CH7057288 induced intracranial tumour regression and greatly improved event-free survival. CH7057288 can be used as a therapeutic agent for TRK fusion-positive cancers. The TRK receptor tyrosine kinase is expressed in a variety of cancer types, including lung and colorectal cancers, in the form of fusion proteins encoded by various fusion genes[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.76mL

0.35mL

0.18mL

8.78mL

1.76mL

0.88mL

17.55mL

3.51mL

1.76mL
参考文献

[1]Hiroshi Tanaka, et al. Abstract 4179: Potent and selective TRK inhibitor CH7057288. AACR Annual Meeting 2017; April 1-5, 2017.