JZP-430

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Chemical Structure| 1672691-74-5 同义名 : -
CAS号 : 1672691-74-5
货号 : A1176441
分子式 : C16H26N4O3S
纯度 : 99%+
分子量 : 354.468
MDL号 : MFCD28502436
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(296.22 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 JZP-430 is an effective, highly selective, and irreversible inhibitor of ABHD6, with an IC50 value of 44 nM, approximately 230 times more selective than FAAH and LAL[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.82mL

0.56mL

0.28mL

14.11mL

2.82mL

1.41mL

28.21mL

5.64mL

2.82mL
参考文献

[1]Patel JZ, et al. Optimization of 1,2,5-thiadiazole carbamates as potent and selective ABHD6 inhibitors. ChemMedChem. 2015 Feb;10(2):253-65.