DG-041

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Chemical Structure| 861238-35-9 同义名 : -
CAS号 : 861238-35-9
货号 : A1168303
分子式 : C23H15Cl4FN2O3S2
纯度 : 99%
分子量 : 592.317
MDL号 : MFCD18251534
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 250 mg/mL(422.07 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 DG-041 is a potent, high affinity and selective EP3 receptor antagonist with IC50s of 4.6 nM and 8.1 nM in binding and FLIPR assays, respectively. DG-041 inhibits the promotion of platelet aggregation by PGE2. DG-041 also crosses the blood-brain barrier[1][2].DG-041 has a weak antagonistic effect on DP1, EP1 and TP receptors with IC50 values of 131 nM, 486 nM and 742 nM, respectively[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.69mL

0.34mL

0.17mL

8.44mL

1.69mL

0.84mL

16.88mL

3.38mL

1.69mL
参考文献

[1]Singh J, et al. Antagonists of the EP3 receptor for prostaglandin E2 are novel antiplatelet agents that do not prolong bleeding. ACS Chem Biol. 2009 Feb 20;4(2):115-26.

[2]Hategan G, et al. Heterocyclic 1,7-disubstituted indole sulfonamides are potent and selective human EP3 receptorantagonists. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6797-800.