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PF-06747711

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Chemical Structure| 1892576-58-7 同义名 : -
CAS号 : 1892576-58-7
货号 : A1167892
分子式 : C26H26F3N5O2
纯度 : 99%+
分子量 : 497.512
MDL号 : MFCD31697703
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 40 mg/mL(80.4 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 PF-06747711 is a potent, selective and orally active RORγt inverse agonist with an IC50 of 4.1 nM and possesses anti-skin inflammatory activity. PF-06747711 reduces IL-17 production by human Th17 cells with an IC50 of 9.5 nM[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.01mL

0.40mL

0.20mL

10.05mL

2.01mL

1.01mL

20.10mL

4.02mL

2.01mL
参考文献

[1]Schnute ME, et al. Discovery of 3-Cyano- N-(3-(1-isobutyrylpiperidin-4-yl)-1-methyl-4-(trifluoromethyl)-1 H-pyrrolo[2,3- b]pyridin-5-yl)benzamide: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor C2 Inverse Agonist. J Med Chem. 2018 Sep 9.