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Enzalutamide carboxylic acid

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Chemical Structure| 1242137-15-0 同义名 : MDV3100 carboxylic acid
CAS号 : 1242137-15-0
货号 : A1167488
分子式 : C20H13F4N3O3S
纯度 : 99%+
分子量 : 451.394
MDL号 : MFCD28411442
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(265.84 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Enzalutamide carboxylic acid (MDV3100 carboxylic acid) is identified as an inactive metabolite of Enzalutamide (MDV3100), an androgen receptor (AR) antagonist[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.22mL

0.44mL

0.22mL

11.08mL

2.22mL

1.11mL

22.15mL

4.43mL

2.22mL
参考文献

[1]van Nuland M, et al. Exposure-Response Assessment of Enzalutamide and Its Major Metabolites in a Real-World Cohort of Patients with Metastatic Castration-Resistant Prostate Cancer. Pharmacotherapy. 2019 Dec;39(12):1137-1145.