(-)-Viloxazine HCl
产品说明书
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同义名 : | - |
| CAS号 : | 56287-61-7 | |
| 货号 : | A1167355 | |
| 分子式 : | C13H20ClNO3 | |
| 纯度 : | 99%+ | |
| 分子量 : | 273.756 | |
| MDL号 : | N/A | |
| 存储条件： |
Pure form Inert atmosphere,Room Temperature In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | (S)-Viloxazine Hydrochloride is S(+)-isomers of the atypical antidepressant viloxazin (Viloxazine) can as a norepinephrine reuptake inhibitor (NRI). n vitro, viloxazine demonstrated antagonistic activity at 5-HT2B and agonistic activity at 5-HT2C receptors, along with predicted high receptor occupancy at clinical doses. In vivo, viloxazine increased extracellular 5-HT levels in the prefrontal cortex (PFC), a brain area implicated in ADHD (attention deficit/hyperactivity disorder). Viloxazine also exhibited moderate inhibitory effects on the norepinephrine transporter (NET) in vitro and in vivo, and elicited moderate activity at noradrenergic and dopaminergic systems[2]. The AMDP-evaluation suggests that viloxazin has a somewhat more marked and more rapid effect on symptoms of retardation, whereas amitriptyline acts predominantly on depressive mood, disturbances of sleep and vital feelings. The viloxazine blood levels showed a remarkably low inter- and intraindividual variance[3]. Fourteen consecutive daily injections of either the racemate or the S-isomer (2, 5 and 10 mg kg-1 i.p.) significantly improved the acquisition of avoidance behaviour. Racemic viloxazine caused a concentration-dependent (10(-5)-10(-3 M) release of 5-MT without affecting any significant change in the release of either catecholamine[4]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
3.65mL 0.73mL 0.37mL |
18.26mL 3.65mL 1.83mL |
36.53mL 7.31mL 3.65mL |
| 参考文献 |
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