产品说明书
Ralaniten
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同义名 : | EPI-002 |
| CAS号 : | 1203490-23-6 | |
| 货号 : | A1167310 | |
| 分子式 : | C21H27ClO5 | |
| 纯度 : | 97% | |
| 分子量 : | 394.889 | |
| MDL号 : | MFCD30502912 | |
| 存储条件： |
粉末 Inert atmosphere,Store in freezer, under -20°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(265.9 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Ralaniten, also known as EPI-002, is a potent, orally active AR-NTD antagonist. Ralaniten inhibits the transcriptional activity of AR with an IC50 value of 7.4 μM. Ralaniten can be used to study castration-resistant prostate cancer (CRPC)[1][2].At concentrations of 5-35 μM for 2-3 days, Ralaniten reduced AR-dependent proliferation of LNCaP cells, but had no effect on the survival of PC3 human prostate cancer cells that do not express functional AR[1][2].Ralaniten inhibited forskolin-induced AR-NTD transcription in LNCaP cells at concentrations of 10-35 μM for 4 hours of action[1]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.53mL 0.51mL 0.25mL |
12.66mL 2.53mL 1.27mL |
25.32mL 5.06mL 2.53mL |
| 参考文献 |
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