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VU590

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Chemical Structure| 313505-85-0 同义名 : -
CAS号 : 313505-85-0
货号 : A1164165
分子式 : C24H32N4O7
纯度 : 98%
分子量 : 488.534
MDL号 : MFCD00323677
存储条件：

粉末 Keep in dark place,Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(102.35 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 VU590 is a potent, moderately selective inhibitor of ROMK (Kir1.1) with an IC50 value of 290 nM. VU590 also inhibits Kir7.1 with an IC50 of 8 μM[1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.05mL

0.41mL

0.20mL

10.23mL

2.05mL

1.02mL

20.47mL

4.09mL

2.05mL
参考文献

[1]Bhave G, et al. Development of a selective small-molecule inhibitor of Kir1.1, the renal outer medullary potassium channel. Mol Pharmacol. 2011 Jan;79(1):42-50.

[2]Kharade SV, et al. Pore Polarity and Charge Determine Differential Block of Kir1.1 and Kir7.1 Potassium Channels by Small-Molecule Inhibitor VU590. Mol Pharmacol. 2017 Sep;92(3):338-346.