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SC-57461A

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Chemical Structure| 423169-68-0 同义名 : -
CAS号 : 423169-68-0
货号 : A1163855
分子式 : C20H26ClNO3
纯度 : 99%+
分子量 : 363.878
MDL号 : MFCD00951253
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 250 mg/mL(687.04 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 SC-57461A is a potent, orally active, non-peptide selective inhibitor of LTA4 hydrolase with IC50s of 2.5 nM, 3 nM and 23 nM for recombinant human, mouse and rat LTA4 hydrolase, respectively[1].SC-57461A inhibits ionophore-stimulated LTB4 production in whole blood with IC50s of 49, 166 and 466 nM in human, mouse and rat, respectively[1] .
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.75mL

0.55mL

0.27mL

13.74mL

2.75mL

1.37mL

27.48mL

5.50mL

2.75mL
参考文献

[1]Leslie J Askonas, et al. Pharmacological characterization of SC-57461A (3-[methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic acid HCl), a potent and selective inhibitor of leukotriene A(4) hydrolase I: in vitro studies. J Pharmacol Exp Ther. 2002 F

[2]T D Penning. Inhibitors of leukotriene A4 (LTA4) hydrolase as potential anti-inflammatory agents. Curr Pharm Des. 2001 Feb;7(3):163-79.

[3]James F Kachur, et al. Pharmacological characterization of SC-57461A (3-[methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic acid HCl), a potent and selective inhibitor of leukotriene A(4) hydrolase II: in vivo studies. J Pharmacol Exp Ther. 2002 Feb