Tamsulosin HCl

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Chemical Structure| 106463-17-6 同义名 : 盐酸坦索罗辛 ;(R)-(-)-YM12617;LY253351;Omnic;Flomax;Pradif;YM-12617-1;Tamsulosin (hydrochloride);Flomax hydrochloride;Tamsulosin hydrochloride
CAS号 : 106463-17-6
货号 : A116064
分子式 : C20H29ClN2O5S
纯度 : 99+%
分子量 : 444.973
MDL号 : MFCD00922997
存储条件：

Pure form Keep in dark place,Inert atmosphere,Room temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 60 mg/mL(134.84 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：

IP 2% DMSO+2% Tween80+35% PEG300+water 12 mg/mL clear

PO 0.5% CMC-Na 30 mg/mL suspension

生物活性
描述 Tamsulosin hydrochloride is an α1-adrenoceptor blocking agent that exhibits selectivity for α1a-receptors[3]. Tamsulosin attenuates AAA (abdominal aortic aneurysm) formation with increased preservation of elastin and decreased production of pro-inflammatory cytokines[4]. Further, Tamsulosin may increase the risk of dementia in older men with BPH (benign prostatic hyperplasia) [5].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01741454 Ureteral Obstruction Phase 4 Completed - United States, Wisconsin ... 展开 >> University of Wisconsin Madison, Wisconsin, United States, 53792 收起 <<
NCT01294592 - Completed - -
NCT01294592 Prostatic Hyperplasia Phase 4 Completed - -
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.25mL

0.45mL

0.22mL

11.24mL

2.25mL

1.12mL

22.47mL

4.49mL

2.25mL
参考文献

[1]Franco-Salinas G, de la Rosette JJ, Michel MC. Pharmacokinetics and pharmacodynamics of tamsulosin in its modified-release and oral controlled absorption system formulations. Clin Pharmacokinet. 2010 Mar;49(3):177-88.

[2]Okutsu H, Matsumoto S, et al. Effects of tamsulosin on bladder blood flow and bladder function in rats with bladder outlet obstruction. Urology. 2010 Jan;75(1):235-40.

[3]Tsuda Y, Tatami S, Yamamura N, Tadayasu Y, Sarashina A, Liesenfeld KH, Staab A, Schäfer HG, Ieiri I, Higuchi S. Population pharmacokinetics of tamsulosin hydrochloride in paediatric patients with neuropathic and non-neuropathic bladder. Br J Clin Pharmacol. 2010 Jul;70(1):88-101.

[4]Montgomery WG, Spinosa MD, Cullen JM, Salmon MD, Su G, Hassinger T, Sharma AK, Lu G, Fashandi A, Ailawadi G, Upchurch GR Jr. Tamsulosin attenuates abdominal aortic aneurysm growth. Surgery. 2018 Nov;164(5):1087-1092.

[5]Duan Y, Grady JJ, Albertsen PC, Helen Wu Z. Tamsulosin and the risk of dementia in older men with benign prostatic hyperplasia. Pharmacoepidemiol Drug Saf. 2018 Mar;27(3):340-348.