Hh-Ag1.5

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Chemical Structure| 612542-14-0 同义名 : SAg1.5
CAS号 : 612542-14-0
货号 : A1155088
分子式 : C28H26ClF2N3OS
纯度 : 97%
分子量 : 526.04
MDL号 : MFCD12032128
存储条件：

Pure form Keep in dark place,Inert atmosphere,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(95.05 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Hh-Ag1.5 (SAg1.5) acts as a strong agonist of the Hedgehog (Hh) pathway, exhibiting an EC50 value of 1 nM[1]. Hh-Ag1.5 mediated reprogramming activates dormant liver stem cells in uninjured livers to aid in liver failure recovery[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.90mL

0.38mL

0.19mL

9.50mL

1.90mL

0.95mL

19.01mL

3.80mL

1.90mL
参考文献

[1]Randall W King. Roughing Up Smoothened: Chemical Modulators of Hedgehog Signaling. J Biol. 2002 Nov 6;1(2):8.

[2]Abhisek Mitra, et al. A Small Molecule Hedgehog Agonist HhAg1.5 Mediated Reprogramming Breaks the Quiescence of Noninjured Liver Stem Cells for Rescuing Liver Failure. Transl Res. 2019 Mar;205:44-50.

[3]Maria Frank-Kamenetsky, et al. Small-molecule Modulators of Hedgehog Signaling: Identification and Characterization of Smoothened Agonists and Antagonists. J Biol. 2002 Nov 6;1(2):10.

[4]Cynthia M Rominger, et al. Evidence for Allosteric Interactions of Antagonist Binding to the Smoothened Receptor. J Pharmacol Exp Ther. 2009 Jun;329(3):995-1005.